Plate Nº 18 · recorded October 10, 2026

Biology & EvolutionReported finding

First global genome atlas maps hidden microbial life in 362 lakes

An international team has reconstructed nearly 20,000 mitochondrial genomes from roughly 3,660 microscopic species in 362 lakes across 28 countries, creating the first global genome atlas of lake-dwelling microorganisms.

By Priya Raman3 min read545 words

In brief

  1. Nearly 20,000 mitochondrial genomes were reconstructed from about 3,660 species sampled in 362 lakes and reservoirs across 28 countries.
  2. For several organism groups, the atlas identifies between 6 and more than 20 times as many species as currently listed in leading reference databases; about 750 species matched no known group.
  3. The team set a fixed 98.1 percent identity threshold for classifying mitochondrial genomes as a single species.
  4. Traditional microscope-based monitoring of these organisms uses a counting protocol developed in 1958 and cannot reliably distinguish toxic algae from harmless look-alikes.
  5. In 2022, a toxic algal bloom in the Oder River on the German-Polish border killed roughly 360 tonnes of fish.
First global genome atlas reveals overlooked microscopic life in hundreds of lakes and reservoirs
Plate Nº 18First global genome atlas reveals overlooked microscopic life in hundreds of lakes and reservoirs — AI-generated

An international team has reconstructed nearly 20,000 mitochondrial genomes from roughly 3,660 species of microscopic freshwater organisms. The samples came from 362 lakes and reservoirs across 28 countries, forming the first global genome atlas of its kind.

The work, led by Adrian-Stefan Andrei of the University of Zurich, was published in Nature Communications. It highlights how incomplete the scientific record of lake life remains.

How big is the gap?

For several groups of algae and related single-celled organisms, the new atlas identifies between six and more than twenty times as many species as currently appear in the world's leading reference genomic database. Fewer than one in twenty of the recovered genomes could be assigned to a known genus. About 750 species matched no known group at all.

Lead author Lucas Serra Moncadas said: "This shows just how large the gaps in our knowledge still are. Much of the biodiversity that keeps our lakes functioning has simply remained hidden from us to this day and has never been documented."

Why does it matter?

These tiny organisms — algae, amoebae and other protists — convert sunlight into food, consume bacteria and feed the small animals that fish eat. When the ecological balance tips, the consequences can be severe. In 2022, a bloom of toxic microalgae in the Oder River on the German-Polish border killed roughly 360 tonnes of fish.

Traditional monitoring depends on a counting method developed in 1958. A technician identifies each cell under a microscope. The technique is slow, demands scarce expertise and, most importantly, cannot tell a harmless alga from its toxic twin.

"Under the microscope, a harmless alga and its toxic relative can look identical," Andrei said. "Their DNA likely holds the key to telling them apart."

How was the atlas built?

The researchers analyzed 3,400 DNA datasets. They filtered lake water, sequenced every piece of DNA caught on the membrane and used a machine-learning tool to isolate mitochondrial sequences. Mitochondrial genomes are small and easy to reconstruct. They also evolve faster than nuclear DNA, so even closely related species carry clearly different versions.

To keep species assignments consistent across lakes, seasons and studies, the team set a fixed rule: two mitochondrial genomes at least 98.1 percent identical count as the same species.

Could this replace microscope monitoring?

Not yet. The atlas is a reference library, not a finished monitoring tool. Existing DNA tests use molecular "baits" designed for specific groups, so other organisms slip through. The new approach should capture a wider range of species, but it still needs validation against the older methods.

Andrei said the broader goal is faster, more accurate surveillance of lakes and reservoirs. "For more than 60 years, we have seen only a fraction of the life in the lakes and reservoirs that provide drinking water to more than 180 million Europeans," he said. "Soon, a single bottle of lake water could reveal who lives in it, what's new and what's changing."

The authors describe the work as a foundation. As more genomes are added to the dataset, identification should grow faster, cheaper and more reliable. For now, the atlas makes one thing clear: a great deal of the life in our lakes has yet to be named.

via Phys.org Biology (Source)

Filed under

  • genomics
  • freshwater-biodiversity
  • microbial-ecology
  • dna-sequencing
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Priya Raman

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Senior reporter covering industry trends and analytics at SciBeat.

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